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KMID : 0882420050690010039
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Korean Journal of Medicine
2005 Volume.69 No. 1 p.39 ~ p.45
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Usefulness of PIVKA-2 for diagnosis and evaluation of recurrence of hepatocellular carcinoma
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Kim Do-Young
Kim Kyung-Kyu
Chon Chae-Yoon
Han Kwang-Hyub
Kim Ja-Kyung
Ahn Sang-Hoon
Paik Young-Han
Sim Myoung-Ki
Lee Kwan-Sik
Moon Young-Myoung
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Abstract
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Backgroud: Although alpha-fetoprotein (AFP) is most widely used tumor marker for hepatocellular carcinoma (HCC), the sensitivity is about 60~70% in advanced HCC. Furthermore, the specificity of AFP is relatively low. The aim of this study was to evaluate the usefulness of prothrombin-induced by vitamin K absence or antagonist-II (PIVKA-II) in diagnosis of HCC, and of recurrence after curative surgical resection.
Methods:Between April 2001 and March 2004, a total of 245 patients with pathologically confirmed HCC and a total of 267 patients with non-HCC, chronic liver diseases were enrolled.
Results:With cutoff-value 20 ng/mL for AFP and 40 mAU/mL for PIVKA-II, the sensitivity of AFP and PIVKA-II was 48.6% (119/245) and 75.1% (184/245), respectively. The specificity of them was 81.3% (217/267) and 94.8% (253/267), respectively. When AFP and PIVKA-II were combined, the sensitivity and specificity was 83.3% (204/245) and 77.2% (206/267), respectively. For HCC
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KEYWORD
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PIVKA-2, Carcinoma, Hepatocellular
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